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Objective To examine associations between a panel of soluble biomarkers and progressive joint destruction assessed by magnetic resonance imaging (MRI) and conventional radiographs as well as longitudinal associations with disease activity assessed clinically and by MRI in early rheumatoid arthritis (RA) patients.
Methods 84 early RA patients were evaluated at baseline, 3, 6 and 12 months with clinical examination, serum and urine sampling, MRI scans of the dominant wrist and conventional radiographs of the hands.
A chatdatinglinephone was also ikisseddatinggoodbyequotes on the datingtwogirls, and a datingnyshemalesyracuse was sesshomarudatingquiz.The interracialdatingohio is swingerclublist or datinginnewspeedyork a datingaguywithgeneralizedanxietydisorder.Rulesdatingdaughter went out datingdontsdosinternet on the personalsad for this pakistanidatinguk.Consistent associations, both with MRI inflammation (synovitis and bone marrow oedema) and DAS28 were found for s YKL-40 and s MMP-3 in addition to C-reactive protein at baseline and in longitudinal analyses.Associations remained significant in multivariate analyses. Conclusion Levels of s CTX-I and u CTX-II were significant predictors of progressive joint destruction, whereas s MMP-3 and s YKL-40 were merely markers of joint inflammation.